Short term oral toxicity study of napropamide in growing broiler chicks
2003
Roy, S. | Chakraborty, A.K. | Juliet, S. | Das, S. | Mandal, T.K. | Ghosh, T.K. | Basak, D.K. | Duttagupta, R. (West Bengal University of Animal and Fishery Sciences, Nadia (India))
Short term toxicity study was carried out in growing broiler chicks from the age of day 15 to 45 following daily oral administration of napropamide at 300, 400 and 500 mg/kg. Napropamide at all dose levels reduced the feed intake,and body weight gain without affecting feed efficiency. At the dose level of 500 mg/kg it reduced the crude protein retention. At all the dose levels it reduced ether extract digestibility and produced leucocytosis, lymphocytoses, monocytopenia and heteropenia, while at the dose levels of 400 and 500 mg/kg. It reduced the platelet counts and increased the clotting times of blood. It increased residual blood levels of napropamide depending on dose at 7.14 and 21 days post-administration. Fat retained the highest residue followed by heart and kidney tissue in sequence. At all dose levels, it increased the glutamic oxaloacetic transaminase of liver and glutamic pyruvic transaminase activities of heart tissue; while at the dose levels of 400 and 500 mg/kg it increased the glutamic pyruvic transaminase of liver and glutamic oxaloacetic transaminase of heart tissue of broiler chicks. It increased the cytochrome P450 content of liver and kidney microsomal tissues. Histopathological examination revealed that in general napropamide produced congestion around the centrilobular region and central vein, aggregation of lymphocyte in the form of nodule, coagulative necrosis and fatty degeneration in liver tissue, while it produced extensive haemorrhage, vacuolar degenerative changes and hyalinization of tubular epithlium of kidney tissue. The intensity of cytotoxicity is dose dependent. Napropamide at the above dose levels produced graded toxic effect on the growth of chick.
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