Effect of tomato intake on striatal monoamine level in mouse model of experimental Parkinson's disease
2002
"Suganuma, H. (Kagome Co. Ltd., Nishinasuno, Tochigi (Japan). Research Inst.) | Hirano, T. | Arimoto, Y. | Inakuma, T. "
"An ingestion of tomato powder rich in lycopene was examined for its effect on mice with Parkinson's disease-like syndrome induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). To assess the preventive effect of tomato against the MPTP-in-duced selective destruction of dopaminergic nigrostrie, we determined striatal dopamine (DA). A 4-wk ingestion of the experimental diet containing 20% (w/w) lyophilized tomato powders before MPTP treatment prevented a decrease in the DA level. This suggests that the tomato ingestion might serve as a preventive against neurodegenerative diseases such as Parkinson's disease caused by MPTP and other environmental toxins."
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