Antibacterial activity and inhibitory effect on hepatitis B virus of aqueous extracts from Phyllanthus amarus and Phyllanthus urinaria
2001
Bungorn Sripanidkulchai(Khon Kaen University, Khon Kaen (Thailand). Faculty of Pharmaceutical Sciences) | Unchalee Tattawasart(Khon Kaen University, Khon Kaen (Thailand). Faculty of Medicine) | Pramote Thongkrajai(Huachiew Chalermprakiet University, Samut Prakan (Thailand). Faculty of Public Health and Environment) | Pisamai Laupatarakasem(Khon Kaen University, Khon Kaen (Thailand). Faculty of Medicine)
Objective of this study was to compare antibacterial activity and inhibitory effect on hepatitis B virus of aqueous extracts from Phyllanthus amarus and P. urinara. It was found that P. amarus extract had stronger antibacterial activity than P. urinaria extract with minimum bactericidal concentratation (MBC) for Staphyllococcus aureus at 3.91 mg/ml. MBCs of P. amarus extract for Pseudomonas aeruginosa and Shigella species were equal to 31.25 mg/ml. Whereas its MBC for Escherichia coli was 62.5 mg/ml. P. urinaria extract showed weak antibacterial activity on S. aureus with MBC at 62.5 mg/ml. MBCs for other tested bacterial were higher than 125 mg/ml. Moreover, P. amarus extract also revealed more than 1000 times stronger inhibitory effect on hepatitis B virus than P. uriaria extract with IC50 at 1,682 ng/100 (1 which was equivalent to 11.5 (g of dried plant powder before extraction. The results indicated the different potential in pharmacological activity of P. amarus and P. urinaria. Therefore, it is very important to make a correct medicinal plant identification in the study.
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