Attempts for in vivo influence upon the resistance of Escherichia coli after treatment with flavophosholipol and economical traits of its administration under condition of artificial infection in chickens
Lyutskanov, M.(Trakia University, Stara Zagora (Bulgaria)) | Urumova, V.(Thracian University, Stara Zagora (Bulgaria)) | Petrov, V.(Thracian University, Stara Zagora (Bulgaria))
In the conditions of experimental infection with a E. coli 02 strain, isolated from septic chickens and showing multiresistance to a variety of antimicrobial drugs, the effect of different doses of flavophospholipol (FPL) was surveyed. The possibilities for influencing the antibacterial resistance were followed up via monitoring the changes in growth inhibition zones in agar and the minimum inhibitory concentrations (MIC). It was found out that FPL had a relatively weak direct effect on parameters determining the resistance of the challenge strain. It was suggested that its inhibiting influence on the dissemination of the genetic determinants of resistance among microbial population was rather more effective than on the mechanism of resistance, acting at the level of the microbial cell. The features of FPL as growth promoter, acting effectively on weight gain and feed conversion ratio were confirmed.
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