Host tropism of swine foot-and-mouth disease virus in three animal cells
2005
Wu Jinyan, Liu Xiangtao, Hu Yonghao
chinois. 将猪FMDV毒株(O/GD/MSH/86)分别适应牛肾细胞(Bovinekidney,MD-BK)、幼仓鼠肾细胞(Babyhamsterkidney,BHK-21)和猪肾细胞(Porcinekidney,PK-15),研究了FMDV在宿主细胞上的嗜性。结果发现,该毒株在MD-BK细胞上不产生细胞病变(CPE),从细胞液中也未检测到病毒,而在BHK-21和PK-15细胞上能够稳定产生CPE。可见,猪FMDVO/GD/MSH/86毒株不能在MD-BK细胞上增殖,而在BHK-21和PK-15细胞上则增殖较好。
Afficher plus [+] Moins [-]anglais. Swine foot-and-mouth disease virusvFMDVwvO/GD/MSH/86wwere adapted to different cells, MDBK, BHK-21 and PK-15, the host tropism of FMDV was studied. The results showed that no cytopathic effectvCPEwwas detected in MDBK cells, and no virus was determined in cell sap, but the virus could induce stable CPE in BHK-21 and PK-15 cells. Therefore, the swine FMDV couldn’t multiply in MDBK cells, but it could reproduction well in BHK-21 and PK-15 cells.
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