Adrenocortical responses to tumor necrosis factor-alpha and interferon-gamma in cattle
2004
Soliman, M. (Hokkaido Univ., Sapporo (Japan)) | Okamoto, S. | Kitamura, H. | Kushibiki, S. | Kimura, K. | Saito, M.
The responses of plasma cortisol and adrenocorticotropic hormone (ACTH) were examined to intravenous injection of recombinant bovine tumor necrosis factor-alpha (TNF-alpha) and interferon-y (INF-gama) in Holstein cows. INF-gamain-duced dose-dependent rises in the plasma levels of both cortisol and ACTH, while TNF-alpha induced comparable plasma cortisol responses with much smaller rises in plasma ACTH. The results suggest a direct stimulatory action of TNF-alpha on cortisol secretion from the adrenal gland in cattle.
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