Ethyl alpha-D-glucoside increases urine volume and causes renal morphologic changes in rats
2005
Mishima, T. (Gifu Univ. (Japan)) | Katayama, Y. | Takagi, Y. | Ozeki, K. | Hayakawa, T. | Tsuge, H.
Ethyl alpha-D-glucoside (alpha-EG) is a peculiar component in sake, a traditional Japanese alcoholic beverage. In this study, morphological changes in kidney and effects on urine excretion by alpha-EG ingestion were investigated. After the rats were fed with pellet diets containing 10% or 20% alpha-EG dietary level. alpha-EG was detected in urine and urine volume showed significant increase (p<0.05). Kidney weights were increased (p<0.05) and renal tubules were dilated in the rats by alpha-EG ingestion, whereas there was no detectable histopathological damage to renal cells. Plasma uric acid and urea levels were not affected. In conclusion, ingested alpha-EG was excreted in urine, increasing urine volume. Increase in kidney weight related to renal tubule dilation was observed with alpha-EG ingestion without deteriorate changes in the renal cells or functions.
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