Effects of carbon chain structures of fatty acids on their cytotoxicity to breast cancer cells
2006
Wongtangtintharn, S.(Kagoshima Univ. (Japan)) | Oku, H. | Inafuku, M. | Iwasaki, H. | Toda, T.
This study investigated the incorporation of unusual fatty acids into cellular lipids of breast cancer cells and its relevance to cell cytotoxicity. Fatty acids added to the culture medium were preferentially incorporated into triacylglycerols rather than into phospholipids. The length of the main carbon chain appeared to be the critical factor for incorporation into cellular lipids. Incorporation of branched-chain fatty acids was higher than that of cycloalkyl fatty acids, and similar to that of hydroxy fatty acids. The cytotoxicities of branched-chain fatty acids were stronger than those of cycloalkyl or hydroxy fatty acids. Thus, of the fatty acids studied, only branched-chain fatty acids exhibited cytotoxicity against breast cancer cells. These observations suggest that the branched carbon chain structure has some relevance to its cytotoxicity.
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