Effect of Dietary Monascus Koji on the Liver Damage Induced by Bromobenzene in Rats
Oh, J.D.;Yoon, C.G.;Yu, T.S.(Keimyung University, Daegu, Republic of Korea)E-mail:jky446@kmu.ac.kr
In the present study, it is observed that Monascus diet may have a hepatoprotective effect on the liver damage induced by bromobenzene in rats. By treatment with bromobenzene (400 ㎎/㎏, i.p.) once a day for 3 consecutive days, the liver damage was reduced in rats fed 2% Monascus diet, based on the liver functional and histopathological findings. Furthermore, retreatment of bromobenzene to the animals with damaged liver showed higher decreasing rate of hepatic glutathione content and increasing rate of cytochrome P450 dependent aniline hydroxylase activity at 4 h in rats fed 2% Monascus diet than those fed STD diet, and V∧max in glutathione S-transferase was higher in liver of rats fed 2% Monascus diet than those fed STD diet.
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