Expression of galectin-3 in the spinal cords of Lewis rats and NOD mice with experimental autoimmune encephalomyelitis
Kim, H.C.;Joo, H.G.;Moon, C.J.;Ahn, M.J.;Jee, Y.H.;Lim, Y.K.;Shin, T.K.(Cheju National University, Jeju, Republic of Korea)E-mail:shint@cheju.ac.kr | Koh, C.S.(Shinshu University, Matsumoto, Japan)
The aim of this study was to evaluate the expression of galectin-3, one of beta-galactoside-binding proteins, in the experimental autoimmune encephalomyelitis(EAE) model of Lewis rats or non-obese diabetic (NOD) mice. Western blot analysis showed that galectin-3 was weakly expressed in the spinal cords of complete Freund's adjuvant(CFA) immunized control rats. In EAE, however, galectin-3 expression was significantly increased at the peak stage(days 14 post-immunization), while it was decreased slightly at the recovery stage(day 21 post-immunization).
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