Control of canine respiratory and diarrheal disease using egg yolk antibodies II. Immunoprophylatic effect of egg yolk antibodies in mice and dogs
Lee, H.S.;Kim, J.M.;Woo, S.R.;Jung, B.Y.;Cho, Y.S.(National Veterinary Research and Quarantine Service, Anyang, Republic of Korea)E-mail:leehsoo@nvrqs.go.kr | Yoo, H.S.(Seoul National University, Seoul, Republic of Korea) | Yoon, Y.D.;Oh, J.S.(Green Cross Veterinary Science Institute, Yongin, Republic of Korea) | Huh, W.;Mun, Y.S.(Dae Sung Microbiology Laboratory, Euiwang, Republic of Korea)
Immunoprophylatic effect of IgY against B. bronchispetica was proven with 100% preventive rate in mice administrated with IgY with antibody titer 1:640~1:2,560. Intramuscular administration was more efficient than oral administration. This phenomenon was also observed in the therapeutic effects of IgY after challenge with B. bronchseptica in mice. In the field trials with the egg yolk antibodies from hens immunized with combined antigens with B. bronchiseptica and parvovirus, curing rates in dogs with severe clnical signs such as bloody diarrhea were 81.6% and 86.7% by intramuscular or subcutaneous administration of IgY, respectively.
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