CYP450 1A1 and p53 expression and DNA adduct formation in the liver of rats treated with a single dose of aflatoxins
Lee, B.J.;Lee, S.J.;Kim, T.M.;Kim, D.J.;Nam, S.Y.;Hyun, S.H.;Kang, J.K.;Hong, J.T.;Yun, Y.W.(Chungbuk National University, Cheongju, Republic of Korea)E-mail:ywyun@cbnu.ac.kr | Kim, C.K.(National Institute of Toxicological Research, Korea FDA, Seoul, Republic of Korea)
Aflatoxins are produced mainly by Aspergillus flavus and Aspergillus parasiticus that grow in improperly stored cereals. Aflatoxin B₁ (AFB₁) is a potent hepatocarcinogen in a variety of experimental animals including human beings. In spite of a high attention to the hepatocarcinogenecity of AFB₁, the relative toxicity of aflatoxins (AFB₂ and AFG₁) is not fully clarified. Sprague-Dawley male rats were orally administered with AFB₁, AFB₂, and AFG₁ at the dose of 250 μg/kg (additionally including a dose of 1250 μg/kg for AFB₁) body weight.
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