Vasorelaxant effect of fluoxetine in isolated rat aorta
Kim, S.J.;Kang, H.S.;Kim, J.S.(Chonbuk National University, Jeonju, Republic of Korea)E-mail:kimjs@chonbuk.ac.kr
The vasorelaxant effect of serotonin reuptake inhibitor fluoxetine was investigated in rat isolated thoracic aorta. Fluoxetine induced a concentration-dependent relaxation in aorta precontracted with phenylephrine (PE) and KCl. These relaxations were suppressed by removal of the endothelium (-E) or pretreatment of nitric oxide synthase inhibitors, N(G)-nitro-L-arginine (L-NNA) and N(omega)-nitro-Larginine methyl ester (L-NAME), guanylate cyclase inhibitors, methylene blue (MB) and 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one (ODQ), and Ca²+ channel blockers, nifedipine and verapamil, in PE-precontracted +E rings.
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