Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks
Kim, M.Y.;Kim, H.W.;Park, J.H.;Kim, J.S.;Jin, H.;Moon, S.H.;Eu, K.J.;Cho, H.S.;Kang, G.M.;Cho, M.H.(Seoul National University, Seoul, Republic of Korea)E-mail:mchotox@snu.ac.kr | Kim, Y.S.(Hanyang University, Seoul, Republic of Korea) | Kim, Y.C.(Keimyung University, Daegu, Republic of Korea) | Kim, H.Y.(KyungHee University, Suwon, Republic of Korea) | Lee, K.H.(Korea Cancer Center Hospital, Seoul, Republic of Korea)
Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibuthyl phthalate (DBP) on ozone were investigated after 32- and 52-wk exposures using hprt mutation assay. Male and female B6C3F1 mice exposed to ozone (0.5 ppm), NNK (1.0 mg/kg), DBP (5,000 ppm), and two or three combinations of these toxicants 6 h per day for 32- and 52-wk showed increases in the frequencies of TG rlymphocytes compared to the control groups.
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