Influence of Dietary Zinc, Copper and Cadmium Levels on Rat Liver Aryl Sulfotransferase IV Activity
2006
Chung, K.H. (Sahmyook University, Seoul, Republic of Korea), E-mail: [email protected] | Ringer, D.P. (American Cancer Society, Atlanta, GA, U.S.A) | Shin, K.O. (Sahmyook University, Seoul, Republic of Korea)
Aryl sulfotransferase (AST) IV is a liver enzyme involved in detoxication and has been shown to be susceptible to down regulation by a number of hepatotoxic xenobiotics. Studies presented here to investigate the ability of biological and non-biological divalent metal cations on AST IV activity showed that AST IV was strongly inhibited following in vitro or in vivo exposure to Zn(Ⅱ), Cu(Ⅱ). It was found that 0.025~2.5 ㎛ of these metal ions were sufficient to cause 50% of inhibition in vitro in purified AST Ⅳ and 0.25~25 ㎛ of these metal ions in liver cytosolic fractions.
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