Protection of NMDA-Induced Neuronal Cell Damage by Methanol Extract of Myristica Fragrans Seeds in Cultured Rat Cerebellar Granule Cells
2004
Ban, J.Y. (Chungbuk National University, Cheongju, Republic of Korea) | Bang, K.H. (National Institute of Crop Science, RDA, Suwon, Republic of Korea) | Song, K.S. (Kyungpook National University, Daegu, Republic of Korea) | Bae, K.W. (Chungnam National University, Daejeon, Republic of Korea) | Cho, S.O. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, J.Y. (Chungbuk National University, Cheongju, Republic of Korea) | Seong, Y.H. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected] | Seong, N.S. (National Institute of Crop Science, RDA, Suwon, Republic of Korea)
Myristica fragrans seed from Myristica fragrans Houtt (Myristicaceae) has various pharmacological activities peripherally and centrally. The present study aims to investigate the effect of the methanol extract of Myristica fragrans seed (MF) on N-methyl-D-aspartate (NMDA)-induced neurotoxicity in primary cultured rat cerebellar granule neuron. MF, over a concentration range of 0.05 to 5 μg/ml, inhibited NMDA (1 mM)-induced neuronal cell death, which was measured by trypan blue exclusion test and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay.
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