Effect of lithium on endothelial-dependent relaxation to melatonin in rat aorta
2005
Kim, S.J. (Chonbuk National University, Jeonju, Republic of Korea) | Yu, Xian Feng (Chonbuk National University, Jeonju, Republic of Korea) | Cho, I.G. (Chonbuk National University, Jeonju, Republic of Korea) | Kang, H.S. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, J.S. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: kimjs@chonbuk.ac.kr
Melatonin, the principal hormone of the vertebral pineal gland, participates in the regulation of cardiovascular system in vitro and in vivo. Lithium inhibits both inositol polyphosphate phosphatase (IPPase) and inositol monophosphatase (IMPase), which are involved in a wide range of signal transduction pathways. The aim of the present study was to assess the effect of lithium on endothelial-dependent relaxation to melatonin and on the melatonin-induced inhibition of contraction by phenylephrine (PE) in isolated rat aorta. Melatonin induced a concentration-dependent relaxation in PE-precontracted in endothelium-intact (+E) aortic rings.
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