Hypocholesterolemic Soybean Peptide (IAVP) Inhibits HMG-CoA Reductase in a Competitive Manner
2005
Pak, Valeriy V. (Korea Food Research Institute, Seongnam, Republic of Korea) | Koo, M.S. (Korea Food Research Institute, Seongnam, Republic of Korea) | Lee, N.R. (Korea Food Research Institute, Seongnam, Republic of Korea) | Oh, S.K. (Korea Food Research Institute, Seongnam, Republic of Korea) | Kim, M.S. (Korea Food Research Institute, Seongnam, Republic of Korea) | Lee, J.S. (Paichai University, Daejeon, Republic of Korea) | Kwon, D.Y. (Korea Food Research Institute, Seongnam, Republic of Korea), E-mail: [email protected]
Synthesized Ile-Ala-Val-Pro (IAVP) peptide, which has the highest hypocholesterolemic effect among a number of synthesized derivatives of Ile-Ala-Val-Pro-Gly-Glu-Val-Ala (IAVPGEVA) isolated from 11S globulin of soy protein by pepsin digestion, was selected for investigation in the present study. Using a recombinant Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), we studied in detail the inhibition of this enzyme by IAVP and compared the action of this peptide to that of lovastatin, a known competitive inhibitor of this enzyme.
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