Comparative study of karyotype mutability in inbred and outbred rabbits after gamma irradiation
2006
Tanchev, S. | Georgieva, S. | Zhelyazkov, E. | Popov, B.
The purpose of the present study was to perform a comparative analysis of karyotype mutability in inbred and outbred rabbits after gamma irradiation. The rabbits were divided according to their breed, level of inbreeding and genotype features. They all received whole-body irradiation at dose density of 24 cGy/min. 100 Metaphase plates from each rabbit were analysed and the observed structural and ploid chromosome alterations described. Results showed that gamma irradiation at the dose used produced significant increase in chromosome aberrations in inbred animals than in the outbred ones. There was higher % of dicentric chromosomes and polyploidy in the inbred. After irradiation heterogeneous rabbits exhibited higher chromosome stability than the homogeneous groups.
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