Effects of repeated oral administration of sardine oil and cotton seed oil on blood coagulation and platelet aggregation in rats
2006
Matsushita, T.(National Fisheries Univ., Shimonoseki, Yamaguchi (Japan)) | ; Inoue, S. | ; Tanaka, R.
Effects of repeated oral administration of sardine oil and cotton seed oil on blood coagulation and platelet aggregation in rats were examined. Treatments of rats with 3.0g/kg/day of sardine oil and cotton seed oil for 28 days changed the fatty acid composition of lipids in their liver and blood. The levels of n- 3 and n- 6 unsaturated fatty acids showed the tendency to increase and decrease in the rats treated with sardine oil (sardine oil group) in comparison with control rats. Meanwhile, the change in fatty acid composition into the opposite direction was observed in the case of rats treated with cotton seed oil (cotton seed oil group). Treatments of rats with sardine oil and cotton seed oil changed the parameters of thromboelastogram reflecting that whole blood coagulation system was slightly inhibited and enhanced, respectively. These results support that feeding of fish oil including n- 3 unsaturated fatty acids especially eicosapentaenoic acid (EPA) demonstrated anti-thrombus effect due to change in fatty acid composition of lipids. In the present study, adenosine 5'-diphosphoric acid (ADP) -induced platelet aggregation and inhibition of platelet aggregation by a prostaglandin 12 derivative were not influenced by the treatment of rats with sardine oil or cotton seed oil, unexpectedly. Further examination should be needed to clarify the anti-thrombus effect of fish oil.
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