The Roles of PKC-δ on the Regulation of Insulin-Like Growth Factor (IGF)-I and Insulin-Like Growth Factor Binding Protein-3 Secretion by All-Trans Retinoic Acid in MCF-7 Cell
2006
Lee, S.M. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, S.H. (Chonbuk National University, Jeonju, Republic of Korea) | Choi, K.S. (Woosuk University, Wanju, Republic of Korea) | Kang, C.W. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: cwkang@chonbuk.ac.kr
All-trans retinoic acid (AtRA) induces growth inhibition and apoptosis in a variety of tumer cells, including MCF-7 cells. Insulin-like growth factors (IGFs) system has been reported to be associated with the development of cancer. Although MCF-7 cell with AtRA is to be the major stimulus for the cell growth and apoptosis, the mechanism of insulin-like growth factor-I (IGF-I)/insulin-like growth factor binding protein-3 (IGFBP-3) system remains to be elucidated. Thus, this study was conducted to the effect of AtRA on the gene expression and level of IGF-I and IGFBP-3.
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