Effects of Pine Needle Extract Oil on Blood Glucose and Serum Insulin Levels in db/db/Mice
2006
Kim, M.J. (Medvill Central Laboratory, Medvill Co., Ltd, Seoul, Republic of Korea) | Ahn, J.H. (Medvill Central Laboratory, Medvill Co., Ltd, Seoul, Republic of Korea) | Choi, K.H. (Pine Life Engineering, Seoul, Republic of Korea) | Lee, Y.H. (Pine Life Engineering, Seoul, Republic of Korea) | Woo, G.J. (Mo-nature, Seoul, Republic of Korea) | Hong, E.K. (Medvill Central Laboratory, Medvill Co., Ltd, Seoul, Republic of Korea) | Chung, Y.S. (Medvill Central Laboratory, Medvill Co., Ltd, Seoul, Republic of Korea), E-mail: [email protected]
This study was per-formed to investigate the hypoglycemic effect of pine needle extract oil against type 2 diabetes. Six-week-old male C57BL/Ks (db/db)mice were divided into four groups; negative control, pine needle extract oil low dose, high dose and positive control groups, which fed daily for 6 weeks with corn oil, pine needle extract oil 112.5 mg/kg, 450 mg/kg or metformin (150 mg/kg), respectively. The oral administration of the pine needle extract oil resulted in the significant and dose-dependent decreases of blood glucose levels in comparison with corn oil treatment.
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