Histopathological changes of testes and eyes by neutron irradiation with boron compounds in mice
2006
Kim, Y.J. (Chungnam National University, Daejeon, Republic of Korea) | Yoon, W.K. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Ryu, S.Y. (Chungnam National University, Daejeon, Republic of Korea) | Chun, K.J. (Korea Atomic Energy Research Institute, Daejeon, Republic of Korea) | Son, H.Y. (Chungnam National University, Daejeon, Republic of Korea) | Cho, S.W. (Chungnam National University, Daejeon, Republic of Korea), E-mail: [email protected]
This study was performed to investigate the biological effects of boron neutron capture therapy (BNCT) on the testes and eyes in mice using HANARO Nuclear Reactor, Korea Atomic Energy Research Institute. BNCT relies on the high capacity of ∨10B in capturing thermal neutrons. Sodium borocaptate (BSH, 75 ppm, iv) and borono-phenylalanine (BPA, 750 ppm, ip) have been used as the boron delivery agents. Mice were irradiated with neutron (flux: 1.036739E+09, Fluence 9.600200E+12) by lying flat pose for 30 (10 Gy) or 100 min (33 Gy) with or without boron carrier treatment.
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