The effect of whole-body irradiation on the catelcholamine levels in the hypothalamus of sheep
2003
Pastorova, B.,University of Veterinary Medicine, Kosice (Slovak Republic)
The changes in the levels of catecholamines in the hypothalamus of sheep (n=21) after whole-body irradiation with 60Co at a total dose of 6.7 Gy were studied for seven days. A similar decrease in noradrenaline in the hypothalamus of sheep in comparison with the control was observed, most significantly in the rostral (by 74.2 %) and medial parts (by 40 %). A decline was found in dopamine, the levels of which decreased by 72 % in the rostral region, by 94 % in the medial one and by 60 % in the caudal hypothalamus. Our results have allowed us to presume that the whole-body irradiation of sheep decreased the content of catecholamines in the hypothalamus, most likely due to the failure of synthesis and degradation of catecholamines and to damage of the whole organism.
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