Basic mechanisms of the cellular alterations in T-2 toxin poisoning: influence on the choice and result of the therapy
2007
Jacevic, V.M.,Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Bocarov-Stancic, A.S.,Hold. Comp. Center for Bio-Ecology, Zrenjanin (Serbia) | Resanovic, R.D.,Faculty of Veterinary Medicine, Belgrade (Serbia). Institute for Poultry Diseases | Djordjevic, S.B.,Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Bokonjic, D.R.,Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Stojiljkovic, M.P.,Actavis Trading Ltd., Belgrade (Serbia). Representative Office
The aim of this study was to investigate the protective effects of different antidotes and their combinations on 24 hour survival and pathohistological changes in the gut and heart of the rats acutely poisoned with 1.0 LD50 T-2 toxin. In summary, the steroidal anti-inflammatory drugs could be recommended as a regimen of choice for treatment of acute T-2 toxicoses, while the nonsteroidal anti-inflammatory compounds, different absorbent formulations and their combinations with anti-oxidants or radioprotectors could be important for the treatment of subacute and chronic T-2 toxin poisonings.
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