Development of food supplement products from Boesenbergia pandurata (Roxb.) Schltr. and seed capsular of Ocimum canum Sims
2000
Taweesak Suntorntanasat | Khanittha Chawananorasest | Krittiya Thisayakorn | Jakkrapong Limpanussorn | Arkachai Tantrawong | Charus Thisayakorn | Tuanta Sematong | Penmakha Tapanawat
Chemical constituents of crude hexane extract from the underground parts of B. pandurata (Roxb.) Schltr. (BP) were isolated and purified by column chromatographic technique. Pinostrobin was found to be a major component. Monosaccharides were discovered in the seed capsular mucilage of O. canum (OC) by paper chromatographic technique. Preliminary antipyretic studies of the test samples of BP and OC at the same doses 500 mg/kg body weight, compared to positive control (Paracetamol at the dose 250 mg/kg body weight) were conducted in pyretic-yeast induction Wistar rats. The antipyretic activities of Paracetamol, BP and OC were 88.9 percent, 39.0 percent and 44.4 percent respectively. By immunizing male Wistar rats with sheep red blood cell (SRBC) for immunostimulatory study, rats were divided into three groups, (1) Experimental group was gavaged with BP and with OC at the same doses, 500 mg/kg body weight. (2) Positive control group was gavaged with Decaris 150 mg at the dose 5 mg/kg body weight and (3) Negative control group was gavaged with suspension base. The percentages of the detectable antibodies against SRBC in rats, gavaged with Decaris, BP, OC and base suspension were 91.7 percent, 75.0 percent, 75.0 percent and 0 percent, respectively. They were carried out by hemagglutinating test (HA test). The acute oral toxicity study of BP and OC (limit test, OECD guidelines 1993) showed that the growth rate of treated and control rats were in the same ranges. No toxic signs and no mortalities occurred. None of the rats showed gross pathological changes at necropsy.
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