Reaction of the pituitary-adrenal glands chain during adaptation in industrial pig breeding
2008
petkov, P. | Kecheva, R. | Kanakov, D.
The expression of many inducible genes involved in cell growth and differentiation as cytokine genes is regulated mainly by mitogen-activated protein kinases (MARK)- signaling pathways. In this study we examined how JNK (SP600125) and p38(SB202190) MARKs inhibitors influenced the inducible IL-12p40, IL-12p70 and IL-23 production. The quantity determination of these cytokines was performed by ELISA in culture supernatants. The inhibition of p38MARK downrequlated IL-23 production and uprequlated IL-12p40/p70 propduction in stimulated cells. We suggest the benefit of p38 control in the treatment of inflammatory and/or autoimmune disease.
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