[Immunological indicators at oxen immunized with Salmonella abtigens]
2007
Medvedev, A.P. | Darovskikh, S.V. | Korochkin, R.B., Vitebsk State Academy of Veterinary Medicine (Belarus)
Immunobiological properties at oxen immunized with Salmonella antigens indicate an increased immunity response in the animals up to the 10 - 12th injection. The next injections prolong the immunizations period leading to unreasonable material and labor waste. Multiple hyperimmunization of an oxen immunized with Salmonella antigens leads to change of structure of serum of blood of these animals. Thus the quantity of albumines reduces, and content of content of gamma - globulins sharply increases after each of twelve injections of antigens and further almost does not changes. Dynamics of T - lymphocytes in blood of an oxen - producers considerably does not change, quantities of lymphocytes gradually increases after the first, fourth eighth and the twelfth injections of antigen entering and makes 18,2±1,4, 25,8±3,1, 28,8+1,4 and 30,1±2,1 % accordingly. In intensive use of animals (a blood taking in considerable quantities) change of T- and B - lymphocytes was insignificant. In blood of hyperimmunized oxen the greatest quantity of T - lymphocytes register after the second and tenth injection of antigen, and quantity of B - lymphocytes naturally increases with increase of doses of antigen and reaches the maximum value after its tenfold introduction. Agglutinin activity of serum of blood of oxen in the course of hyperimmunization increases with the twelfth, and preventive - after the tenth injection of antigen
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