Effects of levamisole on phagocytic activity of rainbow trout (Oncorhynchus mykiss W.)
2007
Ispir, U.,Firat Univ., Elazig (Turkey). Dept. of Fish Diseases | Yonar, M.E.,Firat Univ., Elazig (Turkey). Dept. of Fish Diseases
Activation of phagocytic cells was examined in Oncorhynchus mykiss exposed to 1, 5 and 10 microg/mL concentrations of levamisole solution. For this purpose, blood samples were taken from fish on days 1, 7 and 14 of exposure. Potential killing activity was determined by measuring oxidative radical production and phagocytic activity of neutrophils and superoxide anion production of phagocytic cells against Yersinia ruckeri. The activity of phagocytic cells in fish exposed to each of the three concentrations was found significantly higher than that in controls. Although no activation in oxidative radical production, phagocytes and bactericidal killing activity in fish exposed to 5 and 10 microg/mL concentrations of levamisole solution was determined on day 7, it was observed that all indicators increased on day 14 of exposure. The present results suggest that the application of levamisole in fish farms could increase non-specific immunity and resistance to infection in fish.
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