Enhanced Virus Safety of a Solvent/Detergent-Treated Antihemophilic Factor IX Concentrate by Dry-Heat Treatment
2006
Shin, J.S. (Green Cross Co., Yongin, Republic of Korea) | Choi, Y.W. (Green Cross Co., Yongin, Republic of Korea) | Sung, H.M. (Green Cross Co., Yongin, Republic of Korea) | Ryu, Y.W. (Ajou University, Suwon, Republic of Korea) | Kim, I.S. (Hannam University, Daejeon, Republic of Korea), E-mail: [email protected]
With particular regards to the hepatitis A virus (HAV), a terminal dry-heat treatment (100℃ for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor Ⅸ concentrate. The loss of factor Ⅸ activity during dry-heat treatment was of about 3%, as estimated by a clotting assay. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor Ⅸ compared with those of the factor Ⅸ before dry-heat treatment.
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