Effect of Pimpinella brachycarpa Extract on Lipid Metabolism in Rats Fed High Cholesterol Diet
2006
Lee, J.J. (Chosun University, Gwangju, Republic of Korea) | Choo, M.H. (Chosun University, Gwangju, Republic of Korea) | Lee, M.Y. (Chosun University, Gwangju, Republic of Korea), E-mail: [email protected]
This study was performed to investigate the effect of ethanol extract of Pimpinella brachycarpa (PB) on serum and liver lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. PB ethanol extract (200 mg/kg/day or 400 mg/kg/day) was also administered orally to rats with high cholesterol diet for 6 weeks. We divided 40 rats into five groups; normal diet group (NC), high cholesterol diet group (HC), normal diet and PB ethanol extract (200 mg/kg) administered group (NC-PB), high cholesterol diet and PB ethanol extract (200 mg/kg) administered group (HC-PBL), and high cholesterol diet and PB ethanol extract (400 mg/kg) administered group (HC-PBH).
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