A Novel Approach to the Production of Hyaluronic Acid by Streptococcus zooepidemicus
2006
Kim, S.J. (Korea University, Seoul, Republic of Korea) | Park, S.Y. (Chong Kun Dang Bio Corporation, Ansan, Republic of Korea) | Kim, C.W. (Korea University, Seoul, Republic of Korea), E-mail: cwkim@korea.ac.kr
It has been shown that the initial conditions of bacterial cultivation are extremely important for the successful production of hyaluronic acid (HA) by fermentation. We investigated several parameters that affect cell growth rate and the productivity and molecular weight of hyaluronic acid--i.e., agitation speed, aeration rate, culture temperature, pH, and pressure--to determine how to optimize the production of HA by Streptococcus zooepidemicus on an industrial scale. Using a 30-1 jar fermentor under laboratory conditions, we achieved maximum HA productivity and biomass when the agitation speed and aeration rate were increased simultaneously.
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