The Development of Papain which is Extremely Stable to Negative Ionic Environment by Directed Molecular Evolution
2006
Kang, W.K. (The University of Hannam, Daejeon, Republic of Korea), E-mail: [email protected] | Hwang, S.D. (Bridgebio Co. Ltd., Daejeon, Republic of Korea) | Kim, H.S. (Bridgebio Co. Ltd., Daejeon, Republic of Korea) | Jeung, J.S. (The University of Hannam, Daejeon, Republic of Korea) | Lee, B.U. (The University of Kosin, Busan, Republic of Korea)
When the papain, which is a sort of Cystein protease, is applied to the outer skin, it decomposes the protein which forms the peeled outer skin and speeds up metabolism. Therefore, it is one of the most important cosmetics compositic which keeps the function of skin normal. When the papain is used in cosmetics with surfactant, the activity of papain in reduced rapidly. In this study, the modified papain with extreme stability negative ionic environment was developed by directed evolution.
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