Hepatoprotective Constituents of Saururus chinensis Roots Against Tacrine-induced Cytotoxicity in Human Liver-derived Hep G2 Cells
2007
Jeong, G.S. (Wonkwang University, Iksan, Republic of Korea) | Li, Bin (Wonkwang University, Iksan, Republic of Korea) | Lee, D.S. (Wonkwang University, Iksan, Republic of Korea) | Kwon, J.W. (Wonkwang University, Iksan, Republic of Korea) | Lee, H.S. (Wonkwang University, Iksan, Republic of Korea) | Kwon, T.O. (Wonkwang University, Iksan, Republic of Korea) | Kim, Y.C. (Wonkwang University, Iksan, Republic of Korea), E-mail: [email protected]
Five lignans, sauchinone (1), di-O-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saururus chinensis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 2, and 5 showed significant protective effects with the EC∧50 values of 74.2±0.9, 111.3±0.8, 64.3±0.8 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC∧50 value of 86.2±0.5 μM.
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