Hypoglycemic and hypolipidemic effects of Saururus chinensis Baill in streptozotocin-induced diabetic rats
2007
Hwang, J.Y. (Inje University, Gimhae, Republic of Korea) | Zhang, J.A. (Inje University, Gimhae, Republic of Korea) | Kang, M.J. (Inje University, Gimhae, Republic of Korea) | Lee, S.K. (Inje University, Gimhae, Republic of Korea) | Kim, H.A. (Amicogen Inc., Jinju, Republic of Korea) | Kim, J.J. (Amicogen Inc., Jinju, Republic of Korea) | Kim, J.I. (Inje University, Gimhae, Republic of Korea), E-mail: fdsnkiji@inje.ac.kr
Saururus chinensis Baill was reported to inhibit α-glucosidase in vitro and flatten postprandial increase in blood glucose in streptozotocin (STZ)-induced diabetic rats. We studied the effect of chronic consumption of S. chinensis Baill on blood glucose and lipid profile in STZ-induced diabetic male rats fed high fat diet. Male rats weighing 100-120 g were fed 30% fat diet with and without 10% freeze-dried leaves of S. chinensis Baill for 7 weeks after 1 week of adaptation. The rats were rendered diabetic by intravenous injection of STZ (60 mg/kg) after 6-week feeding of the assigned diets.
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