Protective Effect of Schizonepeta tenuifolia Briquet Extracts on Oxidative DNA Damage in Human Leucocytes and on Hydrogen Peroxide-induced Cytotoxicity in PC12 Cells
2007
Yoon, M.Y. (Kyungnam University, Masan, Republic of Korea) | Lee, H.J. (Kyungnam University, Masan, Republic of Korea) | Lee, B.B. (Kyungnam University, Masan, Republic of Korea) | Lee, S.M. (Changshin High School, Masan, Republic of Korea) | Kim, J.Y. (Kyungnam University, Masan, Republic of Korea) | Kim, Y.S. (Kyungnam University, Masan, Republic of Korea) | Park, E.J. (Kyungnam University, Masan, Republic of Korea) | Park, H.R. (Kyungnam University, Masan, Republic of Korea), E-mail: [email protected]
The present study was conducted to examine the antioxidant activities and neuroprotective effects of methanolic extracts from Schizonepeta tenuifolia Briquet (STE). STE (100 ㎍/mL) showed 43.33 μM of total phenolic content, 64.43% of radical scavenging activity, and 0.157 of reducing power. In addition, the effect of STE on H₂O₂-induced DNA damage in human leucocytes was evaluated by the comet assay, where STE was a dose dependent inhibitor of DNA damage induced by 200 μM of H₂O₂. The protective effect of STE against H₂O₂-induced oxidative damage on PC12 cells was investigated by an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) reduction assay and lactate dehydrogenase (LDH) release assays.
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