Protective effects of EDTA and EGTA against CCl₄-induced acute hepatotoxicity in mice
2007
Park, S.G. (Kangwon National University, Chuncheon, Republic of Korea) | Cho, Y.D. (Kangwon National University, Chuncheon, Republic of Korea) | Shin, T.K. (Cheju National University, Jeju, Republic of Korea) | Wie, M.B. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: mbwie@kangwon.ac.kr
This study investigated the protective effects of ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), an extracellular calcium chelator, and ethylenediaminetetraacetic acid (EDTA), which chelates calcium and most metal ions, against carbon tetrachloride (CCl₄)-induced acute hepatotoxicity in mice. Mice were treated with EGTA or EDTA at a dose of 20 (low) or 100 mg/kg (high) subcutaneously 1 h before CCl₄ administration. The mice were fasted and sacrificed 18 h after CCl₄ treatment.
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