The recovery effect of polyacetylene constituents from Acanthopanax senticosus extracts on hepatic injury in dogs
2007
Cho, S.N. (Chungnam National University, Daejeon, Republic of Korea) | Liu, Jianzhu (Shandong Agricultural University, Taian, China) | Jun, H.K. (Chungnam National University, Daejeon, Republic of Korea) | Cho, S.W. (Chungnam National University, Daejeon, Republic of Korea) | Chang, K.S. (Chungnam National University, Daejeon, Republic of Korea) | Kim, S.J. (Chungnam National University, Daejeon, Republic of Korea) | Kim, Y.H. (Chungnam National University, Daejeon, Republic of Korea) | Yang, H.J. (Chungnam National University, Daejeon, Republic of Korea) | Kim, D.H. (Chungnam National University, Daejeon, Republic of Korea), E-mail: dhkim@cnu.ac.kr
The present study was performed to clarify the recovery effect of polyacetylene constituents from Acanthopanax senticosus ethanol extracts on CCl₄-induced acute hepatic injury in dogs. Sixteen clinically healthy dogs were divided into the control group (six dogs), and experimental group Ⅰ (three dogs), Ⅱ (three dogs) and Ⅲ (four dogs). Acute hepatic injury was induced by single intraperitoneal injection of 1 ml/kg CCl₄solution (CCl₄: olive oil = 1 : 1) after sterilization. The control group was orally administered with 10 ml of corn oil, and experimental groups Ⅰ, Ⅱ and Ⅲ were orally administered with extracts of A. senticosus at the dose of 5, 10 and 30 mg/kg in 10 ml corn oil for seven consecutive days at 24 h after CCl₄ injection.
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