Cytokine mimetic properties of some Philippine food and medicinal plants
2007
Tulin, E.E. | Ecleo, Z.T., Leyte State Univ., Baybay, Leyte (Philippines). Philippine Root Crop Research and Training Center
This study was conducted to evaluate indigenous plants for cytokine mimetic properties and partially characterize candidate mimetics for their stability as well as their sensitivity to temperature and pH level variations. Forty-five plant extract preparations were evaluated for their ability to stimulate proliferation of mouse spleen and bone marrow cells. Temperature and pH effects were determined by subjecting the extracts to different temperature and pH levels and measuring their residual proliferative activities. Results revealed that 24 and 14 extracts were able to stimulate proliferation of bone marrow cells and spleen cells, respectively. Extracts from yam (Dioscorea alata L.) Dioscoreaceae) roots and leaves, taro (Colocasia esculenta L.) (Araceae) roots, and buyo (Piper betle L.) (Piperaceae) leaf were among the extracts that strongly stimulated poroliferation of both bone marrow cells and splenocytes, increasing the cell concentration significantly. Heating the extracts beyond 40 deg C markedly reduced their proliferative ability while pH level below 4.0 and above 8.0 also significantly decreased extracts activity. Three protein mimetics of sizes 26 kDa, 35 kDa, and 50 kDa were isolated from buyo leaf, yam root, and taro root extracts, respectively. All three molecules are biologically active and stimulate a dose-dependent proliferative response.
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