Effect of estradiol or calcium treatment on mammotrophs of female middle-aged rats
2007
Milosevic, V., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Starcevic, V., University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Physiology | Sosic-Jurjevic, B. | Filipovic, B. | Trifunovic, S. | Ristic, N. | Nestorovic, N. | Manojlovic, M. | Sekulic, M., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia)
The effect of estradiol dipropionate (EDP) or calcium glucoheptonate (Ca) on the morphology and stereology of the PRL cells in 14-month-old Wistar female rats were studied. The animals were treated daily with EDP in the dose of 0.625 mg/kg b.w. or calcium glucoheptonate (Ca; 11.4 mg/kg b.w.) for two weeks. Based on the results obtained, it can be concluded that the multiple application of EDP to middle-aged females results in increased morphological parameters of pituitary mammotrophs. However, in calcium treated animals the morphological characteristics of mammotrophs were not significantly changed.
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