Morphological and immunohistochemical assays of surgically removed mammary gland tumours in bitches
2007
Magas, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Jovic, S., Faculty of Veterinary Medicine, Belgrade (Serbia) | Nesic, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Bacetic, D., School of Medicine, Belgrade (Serbia) | Aleksic-Kovacevic, S., Faculty of Veterinary Medicine, Belgrade (Serbia)
In this study an estimation of the malignancy of mammary gland tumors was carried out based upon clinical examination, macroscopic and pathohistological characteristics of neoplasms and expression of cytokeratins. In the study 60 bitches of different ages, race and reproductive status with clinically evident signs of mammary gland tumor were included. The ratio of malignant tumors vs. non-malignant was 1.9:1. The most frequent malignant tumor was adenocarcinoma (n=17) followed by complex adenocarcinoma (n=12), carconoma in mixed tumors (n=5), mucinous carcinoma (n=3), and fibrosarcoma and osteosarcoma, one of each. Most common benign changes were benign mixed tumors (n=10) and adenoma (n=6). Hyperplasia of the mammary gland was found in two bitches, while chronic steatitis, fibrosis and complex adenoma were reported only in individual cases. The expression cytokeratins on different malignant and benign neoplastic cells was determined by the immunohistochemical peroxidase-antiperoxidase method. In simple carcinoma a positive reaction was established within the epithelium of the lumen of the alveoli and in the stromal tumor cells present in the lymph and blood vessels. In the cells pf complex tumors cytokeratin was expressed on epithelial cells as well as on spindle, stellate and myoepithelial cells.
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