Changes in lymphatic organs of layer chickens following vaccination against Marek disease: histological and stereological analysis
2008
Miljkovic, B., Institute of Veterinary Medicine of Serbia, Belgrade (Serbia) | Rakin, A., Institute of Immunology and Virology Torlak, Belgrade (Serbia) | Asanin, R., Faculty of Veterinary Medicine, Belgrade (Serbia) | Dimitrijevic, Lj., Institute of Immunology and Virology Torlak, Belgrade (Serbia) | Micic, M., University of Belgrade, Belgrade (Serbia). Institute for Medical Research
The aim of this study was to investigate histomorphometrical characteristics of the thymus, bursa of Fabricius and spleen in the chickens vaccinated with a vaccine against Marek disease. Vaccination against Marek disease decreased relative mass of the lymphatic organs, and caused significant damage of the thymus and spleen in experimental chickens. In addition, vaccination, similar to Marek disease virus, induced morphometric changes in lymphatic organs. The present data suggest that vaccination against Marek disease was able to induce the immune response in processed organs although it reduced the mass and number of lymphocytes in the major lymphoid organs.
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