The application of adsorbent bentonite in oxidative stress induced by paraquat
2007
Ivanovic, S. | Borozan, S. | Jezdimirovic, M. | Aleksic, N. | Milovanovic, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Tomasevic-Canovic, M., Institute for Technology of Nuclear and Other Raw Materials, Belgrade (Serbia) | Djurdjevic, S., Military Medical Academy, Belgrade (Serbia)
The aim of this study was to investigate the mechanism of toxicity of paraquat after p.o. chronic intoxication in dose of 25 mg/kg. On the results it can be concluded that paraquat provokes oxidative stress that is considerable 1 h and 192 h after the beginning of intoxication with this herbicide. Both natural and synthetic bentonite showed a protective activity in the period from 24 to 144 h after application, acting via external capacity of cationic exchange that is considered to be approximately 10%. The absorption of paraquat depends on the size of the molecule and its polarization and is performed by the mechanisms of ion exchange (ionic and electrostatic interaction). Nevertheless, both absorbents developed a significant protective effect (approximately 50%) 1 h and 192 h after the first application of paraquat, indicating that these protectors act as molecular sieves and thus suppress the process of lipid peroxidation and the development of even more intensive oxidative stress.
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