Blood supply of the insular cortex of Cercopithecus aethiops: another approach to establish non-human primate model for addiction
2008
Filipovic, B., University of Belgrade, Belgrade (Serbia). School of Medicine | Dimitrijevic, I., Clinical Center of Serbia, Belgrade (Serbia) | Djulejic, V., University of Belgrade, Belgrade (Serbia). School of Medicine | Krstic, M., Clinical Center of Serbia, Belgrade (Serbia) | Jurisic, A., Clinics for Obstetrics and Gynecology Narodni Front, Belgrade (Serbia) | Kalezic, N., Clinical Center of Serbia, Belgrade (Serbia) | Teofilovski-Parapid, G., University of Belgrade, Belgrade (Serbia). School of Medicine
The non-human primate model has already been applied in studies about alcoholism in the last decade, demonstrating a high confidence level of similarities between humans and non-human monkeys. Authors indented to establish the definitive model for addiction by investigating the insular blood supply in Cercopithecus aethiops. In 23 out of 24 Latex injected adult brains, the insula received blood supplied by the M2 segment of the middle cerebral artery (MCA). The cortex was supplied by two separate trunks, while perforating branches originating directly from MCA, individually, or together with lateral striate (lenticulostriate) arteries. The average caliber was about 120 microm, and the number of its branches ranged from 2 to 9. No left - right asymmetries have been recorded. Similarities with the human vascular pattern have been studied.
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