Residues of enrofloxacin and its main metabolite ciprofloxacin in broiler chickens
2006
Petrovic, J., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Baltic, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Cupic, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Stefanovic, S., Institute of Meat Hygiene and Technology, Belgrade (Serbia) | Stojanovic, D., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia)
The presence of enrofloxacin residues in muscle and liver after peroral administration of enrofloxacin (10 mg/kg bw/day) to chickens was studied. After oral therapy enrofloxacin, residue levels are 2-4 times higher in the liver than in the meat. Residues mostly consist of enrofloxacin and a smaller quantity of ciprofloxacin. Four days withdrawal period allowed time for the drug concentration, in both meat and liver, to decrease to an acceptable level prior to slaughter (below EU MRL for enrofloxacin and ciprofloxacin). The results of the examining the residues in tissues in treated animals using screening method on Plate pH 8 E coli NCIMB 11595 entirely fulfill the demands of a qualitative method. Examination of tissue samples of treated animals by the screening method gave positive results in all the samples where the residue content was above MRL level.
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