Pharmacokinetics and bioavailability of doxycycline in Thai native chickens
2005
Amnart Poapolathep(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Saranya Poapolathep(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Kanjana Imsilp(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Chartchai Noonpugdee(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Narumol Klangkaew(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Napasorn Kusujarit(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Pharmacology) | Chanin Tirawattanawanich(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Physiology) | Benjamas Subsinsoonthon(Kasetsart University. Bangkhen Campus, Bangkok (Thailand). Faculty of Veterinary Medicine. Department of Microbiology and Immunology)
Pharmacokinetic characteristics of long acting (LA) doxycycline (DOX) formulation were observed in healthy Thai native chickens. Each animal was administered either intravenously (i.v.) or intramuscularly (i.m.) with a single dosage of DOX LA (20 mg/kg body weight). Plasma DOX levels were determined using the agar-well bioassay technique. DOX disposition fitted an open two-compartment model. The maximal plasma concentration (Cmax) was 4.59 +- 0.59 micro g/ml at 20 min with bioavailability of 88.11 +- 3.07 percent after i.m. administration. The elimination half-life (t1/2 and no.946), apparent volume of distribution (Vd), elimination rate constant (kel) and total body clearance (ClB) were 14.13 +- 1.11 h, 0.901 +- 0.027 l/kg, 0.34 +- 0.04/h and 0.31 +- 0.04 l/h/kg, respectively, following i.v. administration. Based on the pharmacokinetic results, therapeutic level of DOX Therefore, the dosage regimen of 20 mg/kg bw administered intramuscularly is recommended every 60 h in Thai native chickens.
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