The molecular mechanism of stress-induced apoptosis in fish cells and embryos: Activation of neutral sphingomyelinase-ceramide pathway
2008
Yabu, T.(National Research Inst. of Fisheries Science, Yokohama (Japan)) | Yamashita, M.
Mechanism of stress-induced apoptosis in fish cultured cells and embryos has been characterized to be regulated by Mgsup(2+)-dependent neutral sphingomyelinase 1. The enzyme hydrolyzes sphingomyelin as a substrate and produces ceramide by its activation through various environmental stimuli, such as heat shock, UV irradiation, gamma-ray irradiation, and C2-ceramide treatment. Such ceramide signaling activates a pro-apoptotic caspase cascade and apoptosis characterized by DNA fragmentation, and resulted in abnormal morphogenesis in fish embryogenesis. Therefore, ceramide signaling functions as the important pro-apoptotic signal in fish development and apoptosis.
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