Quantitative relationship between insecticidal activity and Ca(2+) pump stimulation by flubendiamide and its related compounds
2009
Masaki, T.(Nihon Nohyaku Co. Ltd., Osaka (Japan). Research Center) | Yasokawa, N. | Fujioka, S. | Motoba, K. | Tohnishi, M. | Hirooka, T.
Flubendiamide is the first benzenedicarboxamide compound developed as an insecticide with potent activity against lepidopterous pests. It has already been clarified that insecticidal activity of the compound is mediated through modulation of the ryanodine-sensitive Casup(2+) release channel, (ryanodine receptors; RyRs). The present study showed close correlation between insecticidal activities and stimulating effects on the Casup(2+) pump, a functional co-operative element with RyR activity, and implied the involvement of Casup(2+) pump stimulation in insecticidal activity. This result suggested that Casup(2+) pump activity could be a convenient indicator for determining RyR activity.
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