Study of relationship between abomasal displacement and genetic factors causing heat shock protein 70 (Hsp70) deficiency in Holstein cows
2009
Kato, H.(Nemuro District Agricultural Mutual Relief Assocication, Betsukai, Hokkaido (Japan)) | Ogino, A. | Itoh, T. | Oonisih, M.
The authors investigated whether Hsp70 deficiency, which is a genetic disease occurring in Holstein cows, can cause abomasal displacement in Holstein cows. The subjects were 495 multiparous Holstein cows raised in the Nemuro district of Hokkaido, and had developed abomasal displacement, receiving surgery to reposition the displaced abomasum. For genetic analysis, genotypes were classified into homozygous, heterozygous, and normal by PCR using peripheral blood and hair samples. Sixty cows had a mutation in the gene encoding Hsp70; one cow was homozygous (deficient) and 59 were heterozygous (carriers). The frequency of occurrence of mutations in the Hsp70 gene was calculated as 0.0616. A comparison of this value with the results of an investigation into the Hsp70 mutation between the normal group, at 0.0986, and the survey one revealed a significant difference. We concluded that there was no relationship between Hsp70 deficiency and abomasal displacement.
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