Optimal Extract Condition for the Enhancement of Anticancer Activities of Artemisia princeps Pampanini
2007
Kwon, M.C. (Kangwon National University, Chuncheon, Republic of Korea) | Kim, C.H. (Kangwon National University, Chuncheon, Republic of Korea) | Kim, H.S. (Kangwon National University, Chuncheon, Republic of Korea) | Lee, S.H. (Kangwon National University, Chuncheon, Republic of Korea) | Chio, G.P. (Gangwon Provincial University, Gangneung, Republic of Korea) | Park, U.Y. (Gangwon Provincial University, Gangneung, Republic of Korea) | You, S.G. (Kangnung National University, Kangnung, Republic of Korea) | Lee, H.Y. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: [email protected]
Extractions of Artemisia princeps Pampanini were obtained by using water and ethanol at different temperatures (60℃, 100℃) with or without ultrasonification process (40 kHz). Yield of ultrasonificated extracts were about 20% higher than that of control group. Cytotoxicity of all conditions through adding 1.0 mg/ml was below 37%, and treated with ultrasonification group was lower than the other group, about 5~8%. 100℃ water extract with ultrasonification was higher anticancer activities as maximum 73% and higher selectivities at concentrations over 0.8 mg/ml. The extracts treated with ultrasonification were higher anticancer activities than the control. Densitometric analysis of bcl-2 revealed that extracts of high anticancer activity had low density. This results suggest that expression of bcl-2 protein by adding of Artemisia princeps Pampanini extracts relative to taking cancer. To conclude, optimum condition for efficient extraction of Artemisia princeps Pampanini is using water with ultrasonification at over 60℃ below 100℃.
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